ABSTRACT
OBJECTIVE: The effects of acute continuous positive airway pressure therapy on left ventricular diastolic function and functional capacity in patients with compensated systolic heart failure remain unclear. METHODS: This randomized, double-blind, placebo-controlled clinical trial included 43 patients with heart failure and a left ventricular ejection fraction <0.50 who were in functional classes I-III according to the New York Heart Association criteria. Twenty-three patients were assigned to continuous positive airway pressure therapy (10 cmH2O), while 20 patients received placebo with null pressure for 30 minutes. All patients underwent a 6-minute walk test (6MWT) and Doppler echocardiography before and immediately after intervention. Clinicaltrials.gov: NCT01088854. RESULTS: The groups had similar clinical and echocardiographic baseline variables. Variation in the diastolic function index (e′) after intervention was associated with differences in the distance walked in both groups. However, in the continuous positive airway pressure group, this difference was greater (continuous positive airway pressure group: Δ6MWT = 9.44+16.05×Δe′, p = 0.002; sham group: Δ6MWT = 7.49+5.38×Δe′; p = 0.015). There was a statistically significant interaction between e′ index variation and continuous positive airway pressure for the improvement of functional capacity (p = 0.020). CONCLUSIONS: Continuous positive airway pressure does not acurately change the echocardiographic indexes of left ventricle systolic or diastolic function in patients with compensated systolic heart failure. However, 30-minute continuous positive airway pressure therapy appears to have an effect on left ventricular diastolic function by increasing functional capacity. .
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Continuous Positive Airway Pressure/methods , Diastole/physiology , Heart Failure, Systolic/therapy , Ventricular Function, Left/physiology , Double-Blind Method , Exercise Test , Echocardiography, Doppler/methods , Exercise Tolerance/physiology , Heart Failure, Systolic/physiopathology , Heart Failure, Systolic , Prospective StudiesABSTRACT
Objetivo: Avaliar os efeitos agudos de CPAP na função diastólica ventricular esquerda e tolerância ao exercício em pacientes com insuficiência cardíaca compensada (IC). Métodos: Série de casos (onze pacientes), classe funcional II/III (NYHA). Foram realizados o Teste de caminhada de 6 minutos (TC6), antes e após CPAP (30 minutos; 10 cm H2O), e o ecocardiograma antes e no final do período de CPAP. Os resultados foram comparados pelos testes t pareado ou Wilcoxon, p<0.05. Resultados: CPAP diminuiu a fadiga pré-TC6 (p=0,016) e a dispnéia pós-TC6 (p=0,012). Houve redução do tempo de desaceleração da onda E(p=0,006). Conclusão: CPAP melhora a tolerância aos esforços físicos, em pacientes com IC, provavelmente devido ao efeito na função diastólica ventricular esquerda.